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What Causes Overweight and Obesity?

Lack of Energy Balance

A lack of energy balance most often causes overweight and obesity. Energy balance means that your energy IN equals your energy OUT.

Energy IN is the amount of energy or calories you get from food and drinks. Energy OUT is the amount of energy your body uses for things like breathing, digesting, and being physically active.

To maintain a healthy weight, your energy IN and OUT don't have to balance exactly every day. It's the balance over time that helps you maintain a healthy weight.

The same amount of energy IN and energy OUT over time = weight stays the same

More energy IN than energy OUT over time = weight gain

More energy OUT than energy IN over time = weight loss

Overweight and obesity happen over time when you take in more calories than you use.

Other Causes

An Inactive Lifestyle

Many Peoples aren't very physically active. One reason for this is that many people spend hours in front of TVs and computers doing work, schoolwork, and leisure activities. In fact, more than 2 hours a day of regular TV viewing time has been linked to overweight and obesity.

Other reasons for not being active include: relying on cars instead of walking, fewer physical demands at work or at home because of modern technology and conveniences, and lack of physical education classes in schools.

People who are inactive are more likely to gain weight because they don't burn the calories that they take in from food and drinks. An inactive lifestyle also raises your risk for coronary heart disease, high blood pressure, diabetes, colon cancer, and other health problems.

Environment

Our environment doesn't support healthy lifestyle habits; in fact, it encourages obesity. Some reasons include:

Lack of neighborhood sidewalks and safe places for recreation. Not having area parks, trails, sidewalks, and affordable gyms makes it hard for people to be physically active.

Work schedules. People often say that they don't have time to be physically active because of long work hours and time spent commuting.

Oversized food portions. Americans are exposed to huge food portions in restaurants, fast food places, gas stations, movie theaters, supermarkets, and even at home. Some of these meals and snacks can feed two or more people. Eating large portions means too much energy IN. Over time, this will cause weight gain if it isn't balanced with physical activity.

Lack of access to healthy foods. Some people don't live in neighborhoods that have supermarkets that sell healthy foods, such as fresh fruits and vegetables. Or, for some people, these healthy foods are too costly.

Food advertising.Peoples are surrounded by ads from food companies. Often children are the targets of advertising for high-calorie, high-fat snacks and sugary drinks. The goal of these ads is to sway people to buy these high-calorie foods, and often they do.

Genes and Family History

Studies of identical twins who have been raised apart show that genes have a strong influence on a person's weight. Overweight and obesity tend to run in families. Your chances of being overweight are greater if one or both of your parents are overweight or obese.

Your genes also may affect the amount of fat you store in your body and where on your body you carry the extra fat. Because families also share food and physical activity habits, a link exists between genes and the environment.

Children adopt the habits of their parents. A child who has overweight parents who eat high-calorie foods and are inactive will likely become overweight too. However, if the family adopts healthy food and physical activity habits, the child's chance of being overweight or obese is reduced.

Health Conditions

Some hormone problems may cause overweight and obesity, such as underactive thyroid (hypothyroidism), Cushing's syndrome, and polycystic ovarian syndrome (PCOS).

Underactive thyroid is a condition in which the thyroid gland doesn't make enough thyroid hormone. Lack of thyroid hormone will slow down your metabolism and cause weight gain. You'll also feel tired and weak.

Cushing's syndrome is a condition in which the body's adrenal glands make too much of the hormone cortisol. Cushing's syndrome also can develop if a person takes high doses of certain medicines, such as prednisone, for long periods.

People who have Cushing's syndrome gain weight, have upper-body obesity, a rounded face, fat around the neck, and thin arms and legs.

PCOS is a condition that affects about 5–10 percent of women of childbearing age. Women who have PCOS often are obese, have excess hair growth, and have reproductive problems and other health issues. These problems are caused by high levels of hormones called androgens.

Medicines

Certain medicines may cause you to gain weight. These medicines include some corticosteroids, antidepressants, and seizure medicines.

These medicines can slow the rate at which your body burns calories, increase your appetite, or cause your body to hold on to extra water. All of these factors can lead to weight gain.

Emotional Factors

Some people eat more than usual when they're bored, angry, or stressed. Over time, overeating will lead to weight gain and may cause overweight or obesity.

Smoking

Some people gain weight when they stop smoking. One reason is that food often tastes and smells better after quitting smoking.

Another reason is because nicotine raises the rate at which your body burns calories, so you burn fewer calories when you stop smoking. However, smoking is a serious health risk, and quitting is more important than possible weight gain.

Age

As you get older, you tend to lose muscle, especially if you're less active. Muscle loss can slow down the rate at which your body burns calories. If you don't reduce your calorie intake as you get older, you may gain weight.

Midlife weight gain in women is mainly due to aging and lifestyle, but menopause also plays a role. Many women gain about 5 pounds during menopause and have more fat around the waist than they did before.

Pregnancy

During pregnancy, women gain weight to support their babies’ growth and development. After giving birth, some women find it hard to lose the weight. This may lead to overweight or obesity, especially after a few pregnancies.

Lack of Sleep

Research shows that lack of sleep increases the risk of obesity. For example, one study of teenagers showed that with each hour of sleep lost, the odds of becoming obese went up. Lack of sleep increases the risk of obesity in other age groups as well.

People who sleep fewer hours also seem to prefer eating foods that are higher in calories and carbohydrates, which can lead to overeating, weight gain, and obesity.

Sleep helps maintain a healthy balance of the hormones that make you feel hungry (ghrelin) or full (leptin). When you don't get enough sleep, your level of ghrelin goes up and your level of leptin goes down. This makes you feel hungrier than when you're well-rested.

Sleep also affects how your body reacts to insulin, the hormone that controls your blood glucose (sugar) level. Lack of sleep results in a higher than normal blood sugar level, which may increase your risk for diabetes.

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Complete Diabetes

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Read the complete article and yourself can understand how our medicine can give you an permanent cure.

Insulin is the main regulator of sugar in the bloodstream.

This hormone is made by beta cells and is continuously released into the blood stream. Beta cells are found in the pancreas, which is an organ behind the stomach. Insulin levels in the blood stream are carefully calibrated to keep the blood glucose just right.

High insulin levels drive sugar into muscle, fat and liver cells where it is stored for future use. Low insulin levels allow sugar and other fuels to be released into the blood stream.

Overnight and between meals, insulin levels in the blood stream are low and relatively constant. These low levels of insulin allow the body to tap into its stored energy sources (namely glycogen and fat) and also to release sugar and other fuels from the liver. This overnight and between-meal insulin is referred to as background or basal insulin. When you haven’t eaten for a while, your blood sugar level will be somewhere between 60 to 100 mg/dl.

When eating, insulin is rapidly released from the pancreas. The burst of insulin that accompanies eating is called bolus insulin. After a meal, blood sugar levels peak at less than 140 mg/dl and then fall back to the baseline (pre-meal) range. The high levels of insulin help the sugar get out of the blood stream and be stored for future use.

There are other hormones other than insulin that affect the blood sugar levels in your body. It is important to know about glucagon, amylin, GIP, GLP-1, epinephrine, cortisol, and growth hormone.

There are other hormones other than insulin that affect the blood sugar levels in your body. It is important to know about glucagon, amylin, GIP, GLP-1, epinephrine, cortisol, and growth hormone

Insulin levels throughout the day

To keep the blood glucose in a narrow range throughout the day, there is a low steady secretion of insulin overnight, fasting and between meals with spikes of insulin at mealtimes.  

 There are other hormones that work together with insulin to regulate blood sugar including in cretins and glucocounter regulatory hormones, but insulin is the most important.

During a meal, your liver stores sugar for later.

When you’re not eating, the liver supplies sugar by turning glycogen into glucose in a process called glycogenolysis.

The liver both stores and produces sugar…

The liver acts as the body’s glucose (or fuel) reservoir, and helps to keep your circulating blood sugar levels and other body fuels steady and constant. The liver both stores and manufactures glucose depending upon the body’s need. The need to store or release glucose is primarily signaled by the hormones insulin and glucagon.

During a meal, your liver will store sugar, or glucose, as glycogen for a later time when your body needs it. The high levels of insulin and suppressed levels of glucagon during a meal promote the storage of glucose as glycogen.

The liver makes sugar when you need it….

When you’re not eating – especially overnight or between meals, the body has to make its own sugar. The liver supplies sugar or glucose by turning glycogen into glucose in a process called glycogenolysis. The liver also can manufacture necessary sugar or glucose by harvesting amino acids, waste products and fat byproducts. This process is called gluconeogenesis.

When you’re not eating – especially overnight or between meals, the body has to make its own sugar. The liver supplies sugar or glucose by turning glycogen into glucose in a process called glycogenolysis. The liver also can manufacture necessary sugar or glucose by harvesting amino acids, waste products and fat byproducts. This process is called gluconeogenesis.

The liver also makes another fuel, ketones, when sugar is in short supply….

When your body’s glycogen storage is running low, the body starts to conserve the sugar supplies for the organs that always require sugar. These include: the brain, red blood cells and parts of the kidney. To supplement the limited sugar supply, the liver makes alternative fuels called ketones from fats. This process is called ketogenesis. The hormone signal for ketogenesis to begin is a low level of insulin. Ketones are burned as fuel by muscle and other body organs. And the sugar is saved for the organs that need it.

Glucagon:

Made by islet cells (alpha cells) in the pancreas, controls the production of glucose and another fuel, ketones, in the liver.

Glucagon is released overnight and between meals and is important in maintaining the body’s sugar and fuel balance. It signals the liver to break down its starch or glycogen stores and helps to form new glucose units and ketone units from other substances. It also promotes the breakdown of fat in fat cells.

In contrast after a meal, when sugar from the ingested food rushes into your bloodstream, your liver doesn’t need to make sugar. The consequence Glucagon levels fall.

Unfortunately, in individuals with diabetes, the opposite occurs. While eating, their glucagon levels rise, which causes blood sugar levels to rise after the meal.

WITH DIABETES, GLUCAGON LEVELS ARE TOO HIGH AT MEALTIMES

GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide) and amylin:

 

GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide) and amylin are other hormones that also regulate mealtime insulin. GLP-1 and GIP are incretin hormones. When released from your gut, they signal the beta cells to increase their insulin secretion and, at the same time, decrease the alpha cells’ release of glucagon. GLP-1 also slows down the rate at which food empties from your stomach, and it acts on the brain to make you feel full and satisfied.

People with diabetes have absent or malfunctioning beta cells so the hormones insulin and amylin are missing and the hormone GLP1 cannot work properly. This may explain, in part, why individuals with diabetes do not suppress glucagon during a meal and have high blood sugars after a meal.

Amylin:

Amylin is released along with insulin from beta cells. It has much the same effect as GLP-1. It decreases glucagon levels, which will then decrease the liver’s glucose production, slows the rate at which food empties from your stomach, and makes your brain feel that you have eaten a full and satisfying meal.

The overall effect of these hormones is to reduce the production of sugar by the liver during a meal to prevent it from getting too high.

Epinephrine, cortisol, and growth hormone:

Epinephrine, cortisol, and growth hormone are other hormones that help maintain blood sugar levels. They, along with glucagon (see above) are called “stress” or “gluco-counter-regulatory” hormones – which means they make the blood sugar rise.

Epinephrine (adrenaline) is released from nerve endings and the adrenals, and acts directly on the liver to promote sugar production (via glycogenolysis). Epinephrine also promotes the breakdown and release of fat nutrients that travel to the liver where they are converted into sugar and ketones.

Cortisol is a steroid hormone also secreted from the adrenal gland. It makes fat and muscle cells resistant to the action of insulin, and enhances the production of glucose by the liver. Under normal circumstances, cortisol counterbalances the action of insulin. Under stress or if a synthetic cortisol is given as a medication (such as with prednisone therapy or cortisone injection), cortisol levels become elevated and you become insulin resistant. When you have Type 1 diabetes, this means your may need to take more insulin to keep your blood sugar under control.

Growth Hormone is released from the pituitary, which is a part of the brain. Like cortisol, growth hormone counterbalances the effect of insulin on muscle and fat cells. High levels of growth hormone cause resistance to the action of insulin.

Fasting State:

Ketones:

Ketones and ketoacids are alternative fuels for the body that are made when glucose is in short supply. They are made in the liver from the breakdown of fats.

Ketones are formed when there is not enough sugar or glucose to supply the body’s fuel needs. This occurs overnight, and during dieting or fasting. During these periods, insulin levels are low, but glucagon and epinephrine levels are relatively normal. This combination of low insulin, and relatively normal glucagon and epinephrine levels causes fat to be released from the fat cells.

The fats travel through the blood circulation to reach the liver where they are processed into ketone units. The ketone units then circulate back into the blood stream and are picked up by the muscle and other tissues to fuel your body’s metabolism.

Actually what’s happening :

Brain:

Brain tissue is made up of cell bodies ("gray matter") and the filaments that extend from the cell bodies ("white matter").

Gray Matter:

Brain tissue is divided into two types , gray matter is made up of cell bodies of nerve cells. The volume of gray matter tissue is the measure of the density of brain cells in a particular region.

White Matter:

The white matter is made up of axons and neurons the long filaments that extends from the cell bodies and carry the electrical signals and carry the messages between neurons it’s myelin sheathing makes it look white.

There are three white matter systems, which all connect to form the one continuous system:

Cortical white matter, corpus callosum and the internal capsule

White matter tracts are classified according to their pathways:

Projection tracts encompass those that project from the cortex to non cortical areas, such as the senses and the muscles and those project from the thalamus to the cortex.

Commissural tracts cross one hemisphere to another, through the corpus callosum and the anterior commissure.

Association tracts connects regions within the hemisphere(long ones connects different lobs and short one connect different gyri within the same lobe)

Gray matter is not the sole arbiter of ability and knowledge, of course. The number of neurons is clearly important, but so is the connectivity of the neuronal network. Interestingly, although gray matter declines steadily from adolescence, white matter keeps growing until our late forties. This is consistent with a large-scale study of mental abilities, that found that mental faculties were unchanged, when a marked decline began and continued at a constant rate. Accuracy did not seem to be affected, only speed. White matter governs the speed with which signals travel in the brain.

Neural connections between the hypothalamus and the live...

 

Hypothalamus:

The hypothalamus is a section of the brain responsible for hormone production. The hormones produced by this area of the brain govern body temperature, thirst, hunger, sleep, circadian rhythm, moods, sex drive, and the release of other hormones in the body.

This area of the brain controls the pituitary gland and other glands in the body. This area of the brain is small, but involved in many necessary processes of the body including behavioral, autonomic, and endocrine functions. The hypothalamus' primary function is homeostasis, which is to maintain the body's status quo system-wide. Hypothalamic hormones include thyrotropin-releasing, gonadotropin-releasing, growth hormone-releasing, corticotrophin-releasing, somatostatin, and dopamine hormones.

These hormones release into the blood through the capillaries, traveling to the pituitary gland where their effects are exerted. Oxytocin and vasopressin are also hypothalamic hormones.

The hypothalamus uses a set-point to regulate the body's systems including electrolyte and fluid balance, body temperature, blood pressure, and body weight. It receives inputs from the body, then initiates compensatory changes if anything differentiates from this set-point. The set-point can migrate, but remains remarkably fixed from day-to-day.

The hypothalamus is a part of the brain that has a vital role in controlling many bodily functions including the release of hormones from the pituitary gland.

What hormones hypothalamus produce:

There are two sets of nerve cells in the hypothalamus that produce hormones.  One set sends the hormones they produce down through the pituitary stalk to the posterior lobe of the pituitary gland where these hormones are released directly into the bloodstream.  These hormones are anti-diuretic hormone and oxytosin.  Anti-diuretic hormone causes water reabsorption at the kidneys and oxytocin stimulates contraction of the uterus in childbirth and is important in breastfeeding.

The other set of nerve cells produces stimulating and inhibiting hormones that reach the anterior lobe of the pituitary gland via a network of blood vessels that run down through the pituitary stalk.  These regulate the production of hormones which control the gonads, thyroid gland and adrenal cortex as well as the production of growth   hormone which regulates growth and prolactin which is essential for milk production. 

The hormones produced in the hypothalamus are Corticotrophin-releasing hormone, dopamine, growth hormone-releasing hormone, somatostain, gonadotrophin-releasing hormone and thyrotrophin-releasing hormone.

What could go wrong with hypothalamus:

Hypothalamic function can be affected by head trauma, brain tumors, infection, surgery, radiation and malnutrition.  It can lead to disorders of energy balance and thermoregulation, disorganised body rhythms, (insomnia) and symptoms of pituitary deficiency due to loss of hypothalamic control. 

Pituitary deficiency (hypopituitarism) ultimately causes a deficiency of hormones produced by the gonads, adrenal cortex and thyroid gland as well as loss of growth hormone.

Lack of anti-diuretic hormone production by the hypothalamus causes DIABETIC INSIPIDUS.  In this condition the kidneys are unable to reabsorb water which leads to excessive production of dilute urine and very large amounts of drinking

The hypothalamus is connected to the pituitary gland in two ways. One is via the hypophyseal portal system, which is a system of blood vessels that connects parts of the hypothalamus to the anterior pituitary gland. The hypothalamus secretes hormones into this portal system and the hormones act on the anterior pituitary to trigger the synthesis/secretion of pituitary hormones.

The other is a direct anatomical connection between the hypothalamus and the posterior pituitary gland. In fact, the posterior pituitary gland is actually just an extension of the hypothalamus. When we talk about hormones released by the posterior pituitary, we're actually talking about hormones made and released by the hypothalamus. It just so happens that with the naked eye, it looks like the anterior and posterior pituitary are all part of one big pituitary gland.

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Our medicine increase the neural count in the brain helps white matter tracts and take the hormone activation signals from hypothalamus to the liver.

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Contact Details:

Dr.Msethukannan Ph.D
Udayam Herbo Care,
Run by Udayam Trust,
No 712 jamindar complex Madurai Road 

Theni-625531

Tamilnadu ,India.

Email:sethus@dr.com

Mobile:9566699918

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